Many people are confused about different chemicals and their solubility. When speaking of a fat-soluble chemical, it merely means that the chemical will travel through non-polar substances such as fat cells positively to reach the bloodstream. This process happens during digestion in the lymphatic system, and as such you do not need to take Aniracetam or any other “fat-soluble” chemical with oil or with food in order for it to work. We have fat storage in our bodies at all times, so assuming that you need to take extra with your chemicals is foolish and a strange myth to continue for so long. One other fact about fat-soluble chemicals i that if they are taken in excess our body stores them in our body tissue, so taking large doses of fat-soluble chemicals like Aniracetam and Pramiracetam will cause our bodies to store it to be released at a time when our body can handle more. This happens very rarely with Aniracetam, but the low dosage of Pramiracetam can cause this to happen in some cases. This can cause a delayed or repeating reaction without taking a second dose of the chemical.
Water-soluble chemicals can travel through water, which makes up over 70% of our body, and have been known to be more fast acting when taken orally because it is available to travel through the intestinal walls to our bloodstream directly. The breakdown is such:
Water-Soluble: Faster digestion, lower potency, lower half-life.
Fat-Soluble: Slower digestion, higher potency, higher half-life.
Aniracetam is an exception to this rule only due to its actual chemical compound and not its fat-solubility.
Toxicity is always an issue to be covered when supplementing as there are some chemicals that walk a fine line between benefiting and damaging your body. Nootropics in particular happen to be known for having an extremely low toxicity in most cases. It is possible to not only overdose, but go much farther then that. Studies to find the toxicity levels of racetams led to very optimistic results. When tested on rats through IV, they reached levels as high at 8g/kg and orally up to 10g/kg with no toxic effects.
This can translate to roughly 1 to 1.5 pounds of chemical for a 150 pound man to dose. This and other studies brought scientists to consider chemicals such as these “safer then salt” and can be taken almost ad nauseum. If a supplement I study and write on is dangerous in higher doses that does not mirror the toxicity of nootropics I will state so.
Acetylcholine is a biochemical and functions as a neurotransmitter. It is created in your brain by Cholinergic neurons but must attach to a receptor site in order to carry a signal. Acetylcholine carries tiny electrical signals through the space in between neurons, known as a synapse. It is also a transportation vessel for signals traveling from the brain to a muscle cell, where it triggers muscle contractions.
There are two types of acetylcholine receptors, nicotinic and muscarinic. While both react to Acetylcholine, the nicotinic receptors, as you would expect, react to nicotine, the common chemical that attributes to cigarettes’ addictiveness.
Acetylcholine also has a large hand in regulating memory in the brain, and can be synthesized from Choline, and supplementing with Choline can help induce this reaction along with other chemicals.
If you are looking for more information on Acetylcholine, you can download a .pdf that goes into great detail about the chemical and its functions HERE.